传染病

肿瘤（74）

血液病

免疫

荷尔蒙失调

营养障碍

代谢紊乱

中枢神经系统

眼科

耳鼻喉疾病

心血管

呼吸系统

胃肠道

皮肤科

肌肉骨骼疾病

生殖泌尿系统和性激素

女性健康

男性健康

毒理学

遗传病

口腔和牙齿疾病

非恶性疾病

未公开

其他疾病

血液肿瘤（5）

实体瘤（18）

防止器官移植排斥

胆管癌

胶质瘤

急性髓细胞白血病

软骨肉瘤

寻常痤疮

皮肤病

传染病

指甲病

甲癣

甲状腺炎

甲状腺肿

甲状腺瘤

特应性皮炎

多发性骨髓瘤

乳腺癌（7）

卵巢癌

急性粒细胞白血病

胰腺癌（8）

骨髓增生异常综合征

转移性乳腺癌

肝硬化

非酒精性脂肪性肝炎

肝纤维化

胰腺炎

银屑病

类风湿性关节炎

系统性红斑狼疮

移植物抗宿主病

寻常性天疱疮

急性骨髓性白血病

腋部多汗症

2019年冠状病毒病（新冠病毒-19）

慢性荨麻疹或荨麻疹

非霍奇金淋巴瘤

B细胞淋巴瘤

大疱性表皮松解症

雄激素性脱发

血液学肿瘤

瘙痒症

化疗引起的粒细胞减少症

干燥综合征

系统性硬化症

尿毒症（肾）瘙痒症

非小细胞肺癌（9）

结直肠癌（6）

黑色素瘤（5）

肝癌

小细胞肺癌

肝细胞癌

神经母细胞瘤

脂代谢紊乱

疼痛

慢性铍病（铍中毒）

结节病

非特定B细胞淋巴瘤

肺癌

前列腺癌

间变性星形细胞瘤、多形性胶质母细胞瘤、肾癌、结直肠癌、黑色素瘤、胰腺癌、骨髓增生异常综合征、实体瘤、高级别胶质瘤、儿童弥漫性桥脑胶质瘤

肿瘤裂解综合征

特应性皮炎（特应性湿疹）

T细胞淋巴瘤

非小细胞肺癌；黑色素瘤

头颈癌

社区获得性肺炎

耐甲氧西林金黄色葡萄球菌感染

转移性黑色素瘤

软组织肉瘤

骨肉瘤

默克尔细胞癌

三阴性乳腺癌

贫血

阿尔兹海默症

痴呆症

与阿尔茨海默症相关的痴呆

DNA病毒感染

腺病毒感染

乙肝病毒感染

SARS冠状病毒感染

退化

老化；阿尔茨海默氏病；痴呆症

阿尔茨海默症

帕金森病

亨廷顿病

肌萎缩侧索硬化症

原发性进行性多发性硬化症

转移性非小细胞肺癌

转移性肺癌

溃疡性结肠炎

帕金森病痴呆症

骨质疏松症

绝经后骨质疏松症

骨折

乙型肝炎

肺部肿瘤

脱发症

炎症性肠病

艰难梭菌感染（艰难梭菌相关疾病）

慢性阻塞性肺疾病

非酒精性脂肪性肝炎（NASH）

高尿酸血症

短肠综合征

坏死性小肠结肠炎

自身免疫性疾病

类风湿性关节炎；多发性硬化症；系统性红斑狼疮

脂肪肝

头颈部肿瘤；转移性大肠癌；转移性胃癌

转移性结肠癌

阿尔茨海默病

脑癌

恶性胶质瘤

炎症性疾病；炎症性肠病；自身免疫性疾病

进行性核上麻痹

脑外伤

额颞叶痴呆症

肝脏疾病

骨科疾病

骨科肿瘤

神经系统疾病

中枢神经系统疾病

脑部疾病

丙型肝炎

预防性治疗

免疫接种

疫苗接种

精神病

情绪障碍

抑郁症

严重抑郁症

自杀倾向

卵巢肿瘤

胰腺肿瘤

转移性结直肠癌（9）

胶质母细胞瘤

糖尿病

胰岛素依赖型糖尿病

肥胖症

肥大症

类癌综合征

非酒精性脂肪肝

淋巴瘤

肾脏毒性

药物引起的神经毒性

肾脏纤维化

糖尿病并发症

肌肉骨骼疾病

关节疾病

骨关节炎

代谢紊乱

胰岛疾病

乳腺肿瘤（9）

腹水

膀胱肿瘤

转移性胃癌

神经内分泌肿瘤

糖尿病；肥胖

非酒精性脂肪肝；非酒精性脂肪性肝炎

关节炎

结直肠肿瘤

晚期实体肿瘤

胃癌（7）

食道肿瘤

原发性高草酸尿症

癌症

脑瘤

RNA病毒感染

晚期实体瘤

急性白血病

转移性胰腺癌

实体肿瘤

低血糖症

肾上腺白质营养不良症

旅行者腹泻

杜氏营养不良症；皮肌炎

多发性肌炎；散发性包涵体肌炎

心血管疾病

内分泌疾病

胃肠道疾病

泌尿生殖系统疾病

生长障碍

妇产科

血液病

免疫系统疾病

感染性疾病

炎症性疾病

代谢性疾病

肿瘤

眼部疾病

呼吸系统疾病

前列腺肿瘤

多形性胶质母细胞瘤

胰腺导管腺癌

2019年冠状病毒病

杜氏囊肿症

尿失禁

膀胱过度活动症

膀胱癌

癌

子宫癌

食管癌

宫颈癌

多发性硬化症

输卵管癌

子宫内膜癌

胃食管（GE）交界癌

冠状病毒感染

肌萎缩侧索硬化

激素难治性前列腺癌

转移性脑癌

唐氏综合症

上皮性肿瘤

肌肉减少症

转移瘤

软骨病

难治性多发性骨髓瘤

复发性多发性骨髓瘤

子宫内膜异位症

子宫肌瘤

路易斯肺癌

肌肉萎缩

神经病理性疼痛（神经痛）

癌症疼痛

化疗诱导的周围神经病变

糖尿病周围神经病变

沟通障碍

语言障碍

自闭症

角膜损伤

角膜溃疡

年龄相关性黄斑变性

湿性年龄相关性黄斑变性

黄斑变性

α-1抗胰蛋白酶缺乏症（A1AD）

炎症

眼部炎症

眼部疼痛

镰状细胞性贫血

过敏性结膜炎

眼痛

干燥性角结膜炎

重症肌无力

病毒性呼吸道感染

青光眼

糖尿病眼病

黄斑水肿

老年性黄斑变性

阵发性夜间血红蛋白尿症

复发性多发性硬化症

过敏性鼻炎

季节性过敏性鼻炎

慢性粒细胞白血病

转移性胰腺导管腺癌

胃食管交界处腺癌

变形肉瘤

转移性尿路膀胱癌

包括肾盂癌、输尿管癌、膀胱癌和尿道癌、骨髓增生性肿瘤

糖尿病性黄斑水肿

干性黄斑变性

湿性黄斑变性

认知障碍

亨廷顿舞蹈症

舞蹈症

过敏

即时型超敏反应

湿性（新生血管性/渗出性）黄斑变性

干眼症

神经肌肉疾病

血友病

因子VII缺乏症

周围动脉闭塞性疾病

缺血性中风

动脉血栓形成

败血症

2019年冠状病毒病（新冠病毒-19）相关急性呼吸窘迫综合征

2019年冠状病毒病（新冠病毒-19）肺炎

高血压

糖尿病黄斑水肿

糖尿病视网膜病变

心肌梗塞

干（萎缩性）黄斑变性

湿（新生血管/渗出性）黄斑变性

心肌梗死

充血性心力衰竭

肺动脉高压

脉络膜新生血管

增殖性糖尿病视网膜病变

先天性人类巨细胞病毒（HCMV）感染

真菌感染

球虫病

特发性肺纤维化

间质性肺病（弥漫性实质性肺病）

背痛

药物依赖

阿片类药物依赖

创伤性脊髓损伤

糖尿病神经性疼痛

肌肉骨骼疼痛

周围神经性疼痛

神经系统疾病；脑部疾病；发作性疾病

癫痫症

兰诺克斯综合症

栓塞和血栓形成

阿尔茨海默病、多发性硬化症、帕金森病

泰伊-萨克斯二氏病

乙型肝炎病毒感染

心房颤动

囊性纤维化

血管性眼病

中风

不稳定型心绞痛

严重下肢缺血

精神分裂症

急性缺血性中风

胃肠道肿瘤

激素难治性（去势抵抗

雄激素非依赖性）前列腺癌

克罗恩斯病

出血和凝血障碍

2019年冠状病毒病(新冠病毒-19)

动脉粥样硬化

血栓形成

可卡因成瘾

失神发作

癫痫性脑病

视神经脊髓炎

糖尿病足溃疡

食道炎

酒精戒断综合症

酒精中毒

严重肢体缺血

2019年冠状病毒病（COVID-19）相关细胞因子释放综合征

慢性咳嗽

支气管扩张

细菌性呼吸道感染

结核分枝杆菌感染

主动脉瓣狭窄

非酒精性脂肪性肝病

慢性肝病

鸦片戒断综合症

2型糖尿病

抗血栓

非酒精性脂肪性肝炎 (NASH)

非酒精性脂肪肝 (NAFLD)

肥胖

慢性阻塞性肺病 (COPD)

过敏性哮喘

慢性哮喘

流感

鼻病毒感染

纤维化

糖尿病神经病变

神经炎症

低血糖

2 型糖尿病

糖尿病性黄斑水肿，湿性（新生血管/渗出性）黄斑变性

偏头痛

干性（萎缩性）黄斑变性

幼年性黄斑变性（Stargardt 病）

人表皮生长因子受体2阴性乳腺癌（HER2-乳腺癌）

乳糜泻

冠状病毒病 2019 (COVID-19) 相关急性呼吸窘迫综合征

冠状病毒病 2019 (COVID-19) 肺炎

接触性皮炎

甲型流感病毒感染

2019 年冠状病毒病 (COVID-19)

冠状病毒病 2019 (COVID-19)

呼吸道合胞病毒 (RSV) 感染

未指明的流感病毒感染

支气管肺发育不良

银屑病关节炎

斑块状银屑病（寻常型银屑病）

复发性多发性硬化症 (RMS)

原发性硬化性胆管炎

1 型糖尿病（青少年糖尿病）

T细胞白血病

滤泡性淋巴瘤

慢性淋巴细胞性白血病 (CLL)

弥漫性大 B 细胞淋巴瘤

T 细胞淋巴瘤

套细胞淋巴瘤

复发性多发性骨髓瘤骨髓瘤

坏疽性脓皮病

高胆固醇血症

糖尿病性肾病

局灶节段性肾小球硬化症 (FSGS)

肢端肥大症

系统性硬化症（硬皮病）

急性冠状动脉综合征

代谢综合征

葡萄膜炎

甲型流感病毒

登革热

狼疮性肾炎

特发性血小板减少性紫癜（免疫性血小板减少性紫癜）

获得性（自身免疫性）溶血性贫血

慢性炎症性脱髓鞘性多发性神经病（CIDP）

格雷夫斯眼病

膜性肾小球肾炎

视神经脊髓炎（德维克综合征）

寻常型天疱疮

神经性疼痛（神经痛）

术后疼痛

骨关节炎疼痛

纤维肌痛（纤维肌痛综合征）

过敏性支气管肺曲霉病

哮喘

脓胸

胸腔积液

鳞状细胞癌

移行细胞癌（尿路上皮细胞癌）

三阴性乳腺癌（TNBC）

体位性低血压

头颈癌 鳞状细胞癌

鳞状非小细胞肺癌

贮袋炎

嗜睡症

非酒精性脂肪性肝病 (NAFLD)

食管鳞状细胞癌 (ESCC)

多形性胶质母细胞瘤 (GBM)

复发性头颈癌

皮肤癌

衰老

肺部感染

鸟分枝杆菌感染

枫糖浆尿病

NASH 和肥胖症

疾病诊断测试

乳腺癌（包括 T-、TDM1 抗性）、头颈癌、前列腺癌、肺癌、胰腺癌、胃癌、CRC 癌、黑色素瘤

Cells Expressing T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E)

Isocitrate Dehydrogenase [NADP] Cytoplasmic (Oxalosuccinate Decarboxylase or Cytosolic NADP Isocitrate Dehydrogenase or IDP or NADP(+) Specific ICDH or IDH1 or EC 1.1.1.42)

Androgen Receptor (Dihydrotestosterone Receptor or Nuclear Receptor Subfamily 3 Group C Member 4 or DHTR or NR3C4 or AR)

Nuclear Factor Erythroid 2 Related Factor 2 (HEBP1 or Nuclear Factor Erythroid Derived 2 Like 2 or NFE2L2 or NRF2)

Tumor Necrosis Factor (Cachectin or TNF Alpha or Tumor Necrosis Factor Ligand Superfamily Member 2 or TNF a or TNF)

Cells Expressing ADP Ribosyl Cyclase/Cyclic ADP Ribose Hydrolase 1 (Cyclic ADP Ribose Hydrolase 1 or T10 or 2' Phospho ADP Ribosyl Cyclase/2' Phospho Cyclic ADP Ribose Transferase or ADP Ribosyl Cyclase 1 or CD38 or EC 3.2.2.6 or EC 2.4.99.20)（2）

DNA Polymerase (EC 2.7.7.7)

DNA

Innovator

Tyrosine Protein Kinase BTK (Bruton Tyrosine Kinase or B Cell Progenitor Kinase or Agammaglobulinemia Tyrosine Kinase or BTK or EC 2.7.10.2)

Tyrosine Protein Kinase ITK/TSK (Interleukin 2 Inducible T Cell Kinase or T Cell Specific Kinase or Kinase EMT or Tyrosine Protein Kinase Lyk or ITK or EC 2.7.10.2)

Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2)

Receptor Type Tyrosine Protein Kinase FLT3 (FMS Like Tyrosine Kinase 3 or FL Cytokine Receptor or Stem Cell Tyrosine Kinase 1 or Fetal Liver Kinase 2 or CD135 or FLT3 or EC 2.7.10.1)

Cholinergic Receptor Muscarinic (Muscarinic Acetylcholine Receptor or CHRM)

Immunoglobulin E (IgE)

E Selectin (CD62 Antigen Like Family Member E or Endothelial Leukocyte Adhesion Molecule 1 or Leukocyte Endothelial Cell Adhesion Molecule 2 or LECAM2 or CD62E or SELE)

Geranylgeranyl Pyrophosphate Synthase (Geranylgeranyl Diphosphate Synthase or Dimethylallyltranstransferase or Farnesyl Diphosphate Synthase or Farnesyltranstransferase or Geranyltranstransferase or GGPS1 or EC 2.5.1.29 or EC 2.5.1.1 or EC 2.5.1.10)

CD3（2）

Cells Expressing Leukocyte Antigen CD37 (Tetraspanin 26 or CD37)

Cells Expressing Tumor Necrosis Factor Receptor Superfamily Member 17 (B Cell Maturation Antigen or CD269 or BCMA or TNFRSF17)

Cannabinoid Receptor 1 (CB1 or CANN6 or CNR1)

Cannabinoid Receptor 2 (CB2 or CX5 or CNR2)

3-Oxo 5-Alpha Steroid 4 Dehydrogenase 2 (5 Alpha SR2 or Steroid 5 Alpha Reductase 2 or Type II 5 Alpha Reductase or SR Type 2 or SRD5A2 or EC 1.3.1.22)

Cells Expressing CD3

ATP Binding Cassette Sub Family G Member 2 (Breast Cancer Resistance Protein or Mitoxantrone Resistance Associated Protein or Placenta Specific ATP Binding Cassette Transporter or Urate Exporter or CD338 or ABCG2)（1）

Substance P Receptor (Tachykinin Receptor 1 or NK 1 Receptor or NK1R or TACR1)

Granulocyte Colony Stimulating Factor Receptor (CD114 or GCSFR or CSF3R)

Cells Expressing Tumor Necrosis Factor Receptor Superfamily Member 13C (B Cell Activating Factor Receptor or BAFF Receptor or BLyS Receptor 3 or BAFFR or CD268 or TNFRSF13C)

Kappa Type Opioid Receptor (KOR1 or OPRK or OPRK1)

Mu Type Opioid Receptor (MOR1 or Mu Opiate Receptor or Mu Opioid Receptor or OPRM1)

Telomerase Reverse Transcriptase (HEST2 or Telomerase Catalytic Subunit or Telomerase Associated Protein 2 or TERT or EC 2.7.7.49)

Transient Receptor Potential Cation Channel Subfamily V Member 1 (Capsaicin Receptor or Vanilloid Receptor 1 or TRPV1)

Transforming Growth Factor Beta 2 (BSC1 Cell Growth Inhibitor or Cetermin or Glioblastoma Derived T Cell Suppressor Factor or Polyergin or TGFB2)

ORAI Calcium Release Activated Calcium Modulator (ORAI)

G Protein Coupled Bile Acid Receptor 1 (G Protein Coupled Receptor GPCR19 or Membrane Type Receptor For Bile Acids or hBG37 or GPR131 or GPBAR1)

Interleukin 12 Receptor (IL12R)

DNA Gyrase (EC 5.99.1.3)

DNA Topoisomerase IV (EC 5.99.1.3)

Interleukin 2 (T Cell Growth Factor or Aldesleukin or IL2)

Cells Expressing Cytotoxic T Lymphocyte Protein 4 (Cytotoxic T Lymphocyte Associated Antigen 4 or CD152 or CTLA4)

Granulocyte Macrophage Colony Stimulating Factor (GMCSF or Colony Stimulating Factor or CSF or Molgramostin or Sargramostim or CSF2)

Cells Expressing Melanoma Associated Antigen 6 (Cancer/Testis Antigen 1.6 or MAGE 6 Antigen or MAGE3B Antigen or MAGEA6)

Melanoma Antigen Recognized By T Cells 1 (Protein Melan A or Antigen SK29 AA or Antigen LB39 AA or MART1 or MLANA)

Tyrosinase (Monophenol Monooxygenase or Tumor Rejection Antigen AB or LB24 AB or SK29 AB or TYR or EC 1.14.18.1)

Erythropoietin Receptor (EPOR)

Beta 2 Microglobulin (B2M)

Microtubule Associated Protein Tau (Neurofibrillary Tangle Protein or Paired Helical Filament Tau or MAPT)

Forkhead Box Protein P3 (Scurfin or FOXP3)

GTPase HRas (GTP And GDP Binding Peptide B or Ha Ras1 Proto Oncoprotein or Harvey Rat Sarcoma Viral Oncoprotein or Transforming Protein p21 or HRAS or EC 3.6.5.2)

GTPase KRas (KRas 2 or Ki Ras or c K Ras or KRAS or EC 3.6.5.2)

GTPase NRas (Transforming Protein N Ras or NRAS or EC 3.6.5.2)

Amyloid Beta A4 Protein (ABPP or APPI or Alzheimer Disease Amyloid Protein or Amyloid Precursor Protein or Amyloid Beta Precursor Protein or Cerebral Vascular Amyloid Peptide or Prea4 or Protease Nexin II or APP)

E3 Ubiquitin Protein Ligase Pellino Homolog 1 (Pellino 1 or Pellino Related Intracellular Signaling Molecule or RING Type E3 Ubiquitin Transferase Pellino Homolog 1 or PELI1 or EC 2.3.2.27)

Glucagon Like Peptide 1 Receptor (GLP1R)

Farnesyl Pyrophosphate Synthase (Farnesyl Diphosphate Synthase or (2E,6E) Farnesyl Diphosphate Synthase or Dimethylallyltranstransferase or Geranyltranstransferase or FDPS or EC 2.5.1.10 or EC 2.5.1.1)

Interleukin 1 Receptor Associated Kinase 3 (IL 1 Receptor Associated Kinase M or IRAK3 or EC 2.7.11.1)

Parathyroid Hormone Receptor

Prostaglandin E2 Receptor EP4 Subtype (Prostanoid EP4 Receptor or PTGER4)

Solute Carrier Family 22 Member 12 (Organic Anion Transporter 4 Like Protein or Renal Specific Transporter or RST or Urate Anion Exchanger 1 or SLC22A12)

Acidic Mammalian Chitinase (Lung Specific Protein TSA1902 or CHIA or EC 3.2.1.14)

Chitotriosidase 1 (Chitinase 1 or CHIT1 or EC 3.2.1.14)

G Protein Coupled Receptor 183 (Epstein Barr Virus Induced G Protein Coupled Receptor 2 or EBI2 or GPR183)

Gamma-Aminobutyric Acid Type A Receptor Subunit (GABA(A) Receptor or GABR)

Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 or EC 2.7.10.1)

Tumor Necrosis Factor Ligand Superfamily Member 10 (Apo 2 Ligand or TNF Related Apoptosis Inducing Ligand or Protein TRAIL or CD253 or TNFSF10)

NADPH Oxidase (NOX or EC 1.6.3.1)（2）

Integrin Alpha V (Vitronectin Receptor Subunit Alpha or CD51 or ITGAV)

Integrin Beta 3 (Platelet Membrane Glycoprotein IIIa or CD61 or ITGB3)

Macrophage Colony Stimulating Factor 1 Receptor (CSF 1 Receptor or Proto Oncogene c Fms or CD115 or CSF1R or EC 2.7.10.1)

Diacylglycerol O Acyltransferase 1 (Diglyceride Acyltransferase 1 or ACAT Related Gene Product 1 or Acyl CoA Retinol O Fatty Acyltransferase or DGAT1 or EC 2.3.1.76 or EC 2.3.1.20)

Tyrosine Protein Kinase Receptor UFO (AXL Oncogene or AXL or EC 2.7.10.1)

Thrombospondin 1 (TSP1 or THBS1)

Somatostatin Receptor (SSTR)

Insulin Receptor (IR or CD220 or INSR or EC 2.7.10.1)

Cells Expressing B Lymphocyte Antigen CD19 (B Lymphocyte Surface Antigen B4 or Differentiation Antigen CD19 or T Cell Surface Antigen Leu 12 or CD19)

Cells Expressing B Lymphocyte Antigen CD20 (B Lymphocyte Surface Antigen B1 or Bp35 or Leukocyte Surface Antigen Leu 16 or Membrane Spanning 4 Domains Subfamily A Member 1 or CD20 or MS4A1)

Cells Expressing Receptor Tyrosine Protein Kinase ERBB 2 (Metastatic Lymph Node Gene 19 Protein or Proto Oncogene Neu or Proto Oncogene C ErbB 2 or Tyrosine Kinase Type Cell Surface Receptor HER2 or p185erbB2 or HER2 or CD340 or ERBB2 or EC 2.7.10.1)（2）

Kelch Like ECH Associated Protein 1 (Cytosolic Inhibitor Of Nrf2 or Inrf2 or Kelch Like Protein 19 or KEAP1)

Transforming Growth Factor Beta (TGFb)

Glucagon Receptor (GL R or GCGR)

Transforming Growth Factor Beta 1 (TGFB1)

Cells Expressing Epithelial Cell Adhesion Molecule (Adenocarcinoma Associated Antigen or Cell Surface Glycoprotein Trop 1 or Epithelial Cell Surface Antigen or Epithelial Glycoprotein 314 or KS 1/4 Antigen or KSA or Tumor Associated Calcium Signal Transducer 1 or CD326 or EPCAM)

Dipeptidyl Peptidase 4 (ADABP or Adenosine Deaminase Complexing Protein 2 or T Cell Activation Antigen CD26 or TP103 or CD26 or DPP4 or EC 3.4.14.5)

Hydroxycarboxylic Acid Receptor 1 (G Protein Coupled Receptor 104 or G Protein Coupled Receptor 81 or GPR104 or GPR81 or HCAR1)

Calcium Channel

R Spondin 3 (Roof Plate Specific Spondin 3 or Protein With TSP Type 1 Repeat or Thrombospondin Type 1 Domain Containing Protein 2 or RSPO3)

Globohexaosylceramide (Globo H)（3）

Vascular Endothelial Growth Factor Receptor 2 (Fetal Liver Kinase 1 or Kinase Insert Domain Receptor or Protein Tyrosine Kinase Receptor flk 1 or VEGFR2 or CD309 or KDR or EC 2.7.10.1)

Dihydroorotate Dehydrogenase (Quinone) Mitochondrial (Dihydroorotate Oxidase or DHODH or EC 1.3.5.2)

Tubulin

Fructose Bisphosphatase (Fructose 1,6 Bisphosphatase or FBPase or EC 3.1.3.11)

Thyroid Hormone Receptor Beta (Nuclear Receptor Subfamily 1 Group A Member 2 or c erbA 2 or c erbA Beta or ERBA2 or THRB)

Cyclin Dependent Kinase 4 (Cell Division Protein Kinase 4 or PSK J3 or CDK4 or EC 2.7.11.22)

Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 2.7.11.22)

Mothers Against Decapentaplegic Homolog 7 (MAD Homolog 7 or Mothers Against DPP Homolog 7 or Mothers Against Decapentaplegic Homolog 8 or SMAD7)

Cells Expressing GTPase KRas (KRas 2 or Ki Ras or c K Ras or KRAS or EC 3.6.5.2)

Heat Shock Protein 90 (HSP90)

Cyclin Dependent Kinase 1 (p34 Protein Kinase or Cell Division Protein Kinase 1 or Cell Division Control Protein 2 Homolog or CDK1 or EC 2.7.11.22 or EC 2.7.11.23)

78 kda Glucose Regulated Protein (Endoplasmic Reticulum Lumenal Ca(2+) Binding Protein Grp78 or Heat Shock 70 kDa Protein 5 or Immunoglobulin Heavy Chain Binding Protein or HSPA5)（1）

Muscarinic Acetylcholine Receptor M3 (CHRM3)

Sialic Acid Binding Ig Like Lectin 15 (CD33 Antigen Like 3 or SIGLEC15)

Cells Expressing CD44 Antigen (CDw44 or Epican or Extracellular Matrix Receptor III or GP90 Lymphocyte Homing/Adhesion Receptor or HUTCH I or Heparan Sulfate Proteoglycan or Hermes Antigen or Hyaluronate Receptor or Phagocytic Glycoprotein 1 or CD44)

Alpha Enolase (2 Phospho D Glycerate Hydro Lyase or C myc Promoter Binding Protein or Enolase 1 or MBP1 or MPB1 or Non Neural Enolase or Plasminogen Binding Protein or ENO1 or EC 4.2.1.11)

Poly [ADP Ribose] Polymerase 1 (ADP Ribosyltransferase Diphtheria Toxin Like 1 or NAD(+) ADP Ribosyltransferase 1 or Poly[ADP Ribose] Synthase 1 or PARP1 or EC 2.4.2.30)

Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30)

Cells Expressing CD276 Antigen (B7 Homolog 3 or 4Ig B7 H3 or Costimulatory Molecule or CD276)

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF)

Cells Expressing Epidermal Growth Factor Receptor (Proto Oncogene c ErbB 1 or Receptor Tyrosine Protein Kinase erbB 1 or HER1 or ERBB1 or EGFR or EC 2.7.10.1)

Peptidyl Prolyl Cis Trans Isomerase FKBP4 (51 Kda FK506 Binding Protein or 52 Kda FK506 Binding Protein or 59 Kda Immunophilin or FK506 Binding Protein 4 or HSP Binding Immunophilin or Immunophilin FKBP52 or Rotamase or p59 or FKBP59 or FKBP52 or FKBP51 or FKBP4 or EC 5.2.1.8)（2）

Interleukin 4 Receptor Subunit Alpha (CD124 or IL4R)

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (Serine/Threonine Kinase MNB or MNB/DYRK Protein Kinase or Dual specificity YAK1 Related Kinase or HP86 or Protein Kinase Minibrain Homolog or DYRK1A or EC 2.7.12.1)

Arginase 1 (Liver Type Arginase or Type I Arginase or ARG1 or EC 3.5.3.1)（1）

Arginase 2 Mitochondrial (Kidney Type Arginase or Type II Arginase or Non Hepatic Arginase or ARG2 or EC 3.5.3.1)

Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor or Heparin Binding Growth Factor 2 or FGF2)

ADP Ribosyl Cyclase/Cyclic ADP Ribose Hydrolase 1 (Cyclic ADP Ribose Hydrolase 1 or T10 or 2' Phospho ADP Ribosyl Cyclase/2' Phospho Cyclic ADP Ribose Transferase or ADP Ribosyl Cyclase 1 or CD38 or EC 3.2.2.6 or EC 2.4.99.20)（1）

Gonadotropin Releasing Hormone Receptor (GNRHR)

Bifunctional Epoxide Hydrolase 2 (Cytosolic Epoxide Hydrolase 2 or Epoxide Hydratase or Soluble Epoxide Hydrolase or Lipid Phosphate Phosphatase or EPHX2 or EC 3.3.2.10 or EC 3.1.3.76)

Voltage Dependent T Type Calcium Channel

Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98)

Chloride Channel

Alpha Synuclein (Non A Beta Component Of AD Amyloid or Non A4 Component Of Amyloid Precursor or NACP or SNCA)

Patatin Like Phospholipase Domain Containing Protein 2 (Adipose Triglyceride Lipase or Calcium Independent Phospholipase A2 or Desnutrin or IPLA2 Zeta or PEDF-R or TTS2.2 or Transport Secretion Protein 2 or ATGL or PNPLA2 or EC 3.1.1.3)

Lactate Dehydrogenase (EC 1.1.1.)

Interferon Gamma (Immune Interferon or IFNG)

Tyrosine Protein Kinase SYK (Spleen Tyrosine Kinase or p72 Syk or SYK or EC 2.7.10.2)

Aminopeptidase N (Myeloid Plasma Membrane Glycoprotein CD13 or Alanyl Aminopeptidase or Aminopeptidase M or Microsomal Aminopeptidase or gp150 or CD13 or ANPEP or EC 3.4.11.2)

Neprilysin (Neutral Endopeptidase 24.11 or Atriopeptidase or Common Acute Lymphocytic Leukemia Antigen or Skin Fibroblast Elastase or Enkephalinase or CD10 or MME or EC 3.4.24.11)

Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5)

Toll Like Receptor 4 (hToll or CD284 or TLR4)

Toll Like Receptor Family (TLR)

Vascular Endothelial Growth Factor A (Vascular Permeability Factor or VEGFA)

Protein Arginine Deiminase Type 4 (HL 60 PAD or PADI H Protein or Peptidylarginine Deiminase IV or PADI4 or EC 3.5.3.15)

Interferon Alpha/Beta Receptor 1 (Cytokine Receptor Class II Member 1 or Cytokine Receptor Family 2 Member 1 or Type I Interferon Receptor 1 or IFNAR1)

Interferon Alpha/Beta Receptor 2 (Interferon Alpha Binding Protein or Type I Interferon Receptor 2 or IFNAR2)

Glucocorticoid Receptor (GR or Nuclear Receptor Subfamily 3 Group C Member 1 or NR3C1)

TGF Beta Receptor Type 1 (Activin A Receptor Type II Like Protein Kinase Of 53kD or Activin Receptor Like Kinase 5 or Serine/Threonine Protein Kinase Receptor R4 or Transforming Growth Factor Beta Receptor Type I or ALK5 or TGFBR1 or EC 2.7.11.30)

Huntingtin (Huntington Disease Protein or HTT)

Alpha Adrenergic Receptor (ADRA)

Beta Adrenergic Receptor (ADRB)

Calcineurin (Protein Serine/Threonine Phosphatase 3 or Protein Phosphatase 3 or EC 3.1.3.16)

Tissue Factor (Coagulation Factor III or Thromboplastin or CD142 or F3)

Atrial Natriuretic Peptide Receptor 1 (Atrial Natriuretic Peptide Receptor Type A or Guanylate Cyclase A or NPR1 or EC 4.6.1.2)

Complement Factor I (C3B/C4B Inactivator or CFI or EC 3.4.21.45)

Vascular Endothelial Growth Factor (VEGF)

Angiopoietin 1 Receptor (Endothelial Tyrosine Kinase or Tunica Interna Endothelial Cell Kinase or Tyrosine Kinase With Ig And EGF Homology Domains 2 or Tyrosine Protein Kinase Receptor TEK or Tyrosine Protein Kinase Receptor TIE 2 or p140 TEK or CD202b or TIE2 or TEK or EC 2.7.10.1)

Chymase (Alpha Chymase or Mast Cell Protease I or CMA1 or EC 3.4.21.39)

Interleukin 21 (Za11 or IL21)

Insulin Like Growth Factor 1 Receptor (CD221 or IGF1R or EC 2.7.10.1)

Insulin Like Growth Factor I (Mechano Growth Factor or Somatomedin C or IGF1)

Nuclear Factor Kappa B (NFKB)

Platelet Derived Growth Factor Subunit B (PDGF2 or Platelet Derived Growth Factor B Chain or Platelet Derived Growth Factor Beta Polypeptide or Proto Oncogene c Sis or Becaplermin or PDGFB)

Tumor Necrosis Factor Receptor Superfamily Member 1B (Tumor Necrosis Factor Receptor 2 or p75 or p80 TNF Alpha Receptor or CD120b or TNFRSF1B)

Vascular Endothelial Growth Factor Receptor 1 (Fms Like Tyrosine Kinase 1 or Tyrosine Protein Kinase Receptor FLT or Tyrosine Protein Kinase FRT or Vascular Permeability Factor Receptor or VEGFR1 or FLT1 or EC 2.7.10.1)

Cadherin 5 (7B4 Antigen or Vascular Endothelial Cadherin or CD144 or CDH5)

Chitin Synthase (EC 2.4.1.16)

DPP4

HER-3

Immunomodulator（7）

Anticancer monoclonal antibody（3）

Isocitrate dehydrogenase gene inhibitor

Anti acne product category

Topical anti-acne product

Antipsoriatic product category

Topical antipsoriatic product

Anti-inflammatory

Non-steroidal anti-inflammatory

Anticancer（3）

DNA polymerase gene modulator

DNA replication pathway modulator

Gene target

Other actions（3）

Protein target（4）

Ras interference interaction gene inhibitor

Kinase suppressor of Ras gene inhibitor

Neurokinin modulator

Granulocyte modulator

DNA damage reversal pathway modulator

Dermatological agent

TRPV1 gene modulator

Cell cycle inhibitor

Immunostimulant（5）

Therapeutic vaccine（4）

TGF beta receptor associated protein 1 modulator

Other dermatological product

EPO gene modulator

Tau protein modulator

Tau deposition inhibitor

Tau aggregation inhibitor

Cell organelle modulator

DNA replication regulation pathway modulator

G protein coupled receptor antagonist

Receptor modulator

Beta amyloid modulator

Autophagy protein gene modulator

Lipid metabolism modulator

Lysosomal-trafficking regulator modulator

Genetic modulator

Gene therapy

Antisense oligonucleotide inhibitor

Ras gene modulator

Tau protein inhibitor

Unspecified drug target

Protein ligand

Unspecified vaccine

Necroptosis inhibitor

Free radical scavenger

Calcium uptake protein modulator

Mitochondrial fission process protein modulator

Pathway modulator

CNS modulator

Nootropic agent

Unspecified receptor modulator

Unspecified receptor agonist

Unspecified receptor antagonist

Putative receptor modulator

Protein FAM modulator

Protein FAM19 modulator

Protein FAM inhibitor

Cell modulator

Signaling molecule modulator

Neuroprotectant

Mitotic cell cycle pathway modulator

Transforming growth factor ligand inhibitor

Enzyme modulator

Enzyme inhibitor

G protein coupled receptor modulator

Gastrointestinal system agent

Biochemical metabolism modulator

ACE inhibitor

Beta amyloid synthesis inhibitor

Beta amyloid antagonist

Amyloid protein deposition inhibitor

Musculoskeletal system modulator

DGAT gene inhibitor

Adjuvant

Antidepressant

AXL gene modulator

Angiogenesis inhibitor

CD47 antagonist

Thrombospondin ligand

DNA vaccine

Hormone modulator

Insulin-like growth factor modulator

Growth hormone ligand inhibitor

Human insulin long acting product

Insulin modulator

Immune recognition receptor modulator

T-cell CD3 glycoprotein zeta chain modulator

Cytostatic

NOX gene inhibitor

Defence protein inhibitor

Reactive oxygen species modulator inhibitor

Immunosuppressant

Anticancer antibody

Cell differentiation stimulator

Apoptosis inhibitor

Immunoglobulin M modulator（3）

Immunoglobulin G modulator（3）

VEGF modulator

Apoptosis pathway modulator（2）

Thyroid hormone modulator

Toxoid vaccine

Adeno-associated virus based gene therapy

Protein synthesis modulator

TGF beta ligand modulator

GDF-8 modulator

Autophagy protein modulator

Cellular process pathway modulator

Defence protein modulator

Reactive oxygen species modulator modulator

Immune recognition receptor antagonist

Cell control agent

PARP gene inhibitor

DNA repair protein modulator

DNA repair protein inhibitor

Androgen modulator

Hepatocyte growth factor ligand

Immunotoxin

Interleukin ligand modulator

Mitosis S phase pathway modulator

Anticancer polyclonal antibody

Cell cycle checkpoint pathway modulator

Bone synthesis modulator

Steroid hormone modulator

Estrogen modulator

Physiological process pathway modulator

Regulatory protein modulator

Histone deacetylase complex modulator

Histone deacetylase complex inhibitor

Ion channel modulator

Stem cell stimulator

Stem cell factor modulator

LDHA gene modulator

Ophthalmological corticosteroid

Topical antiglaucoma agent

Interferon beta ligand modulator

Steroidal anti-inflammatory

siRNA agent

Ocular antineovascularisation agent

Cardiovascular agent

Respiratory system agent

Blood pressure modulator

Bronchodilator

Blood clotting modulator

Platelet aggregation inhibitor

Cell process modulator

Chemokine CXC ligand modulator

Angiogenesis stimulator

Tyrosine kinase receptor modulator

Serine-threonine kinase receptor modulator

Viral vector based gene therapy

Adenovirus based gene therapy

Antimicrobial

Antibacterial

Antiviral

Chemotaxis modulator

Analgesic

Opioid modulator

Pain modulator

Glutamate Ionotropic Receptor (GRI) Antagonist

Voltage Gated Sodium Channel (SCN) Blocker

Gamma-Aminobutyric Acid Type A Receptor Subunit (GABA(A) Receptor or GABR) Agonist

Fibrinolysis stimulator

Factor XI modulator

Lipid uptake modulator

Lipid transporter inhibitor

Lipid transporter modulator

Protein subunit vaccine

HDAC6 inhibitor

Non-viral vector based gene therapy （Cystic Fibrosis Transmembrane Conductance Regulator (ATP Binding Cassette Sub Family C Member 7 or Channel Conductance Controlling ATPase Camp Dependent Chloride Channel or ABCC7 or CFTR or EC 5.6.1.6) Activator）

Vascular leakage blocker by Solvadys™ Technology (Vasoprotectant) Enhanced survival rate of vascular endothelial cells and fundamentally blocked endothelial cell dysfunction through structural modification of actin.

Stabilizes EC junction and strongly block vascular leakage through cAMP/cortactin pathway

Angiogenesis modulator

Antipsychotic

VEGF-A ligand modulator

Vascular agent

undisclosed

Nuclear hormone receptor gene inhibitor

JAK gene modulator

Pemziviptadil (PDP-20418) acts as a vasoactive intestinal polypeptide receptor 2 (VPAC2) agonist. It enhances the activation of G-protein-coupled vasoactive intestinal peptide receptor 2, it activates adenylyl cyclase, potentially triggering the vasodilation of vessels leading to reduction in the blood pressure. The high selectivity for binding to the VPAC2 receptor reduces the potential complications of gastrointestinal side effects believed to be associated with interaction of VIP with the VPAC1 receptor.

PDP-20420 acts by reversing the antiplatelet effect of ticagrelor and AR-C124910XX, the ticagrelor active metabolite (TAM). The drug competes with ticagrelor and TAM for binding with the receptor. Basing on its high affinity towards the receptor, the binding reverses both the antiplatelet activity and the drug-induced bleeding. It also helps to prevent the formation of blood clots and reduces the occurrence of thrombotic events.

Nucleolin modulator

Glutamate Ionotropic Receptor NMDA Type Subunit (NMDAR or GRIN) Antagonist

Von Willebrand Factor (VWF) Inhibitor

G protein coupled receptor agonist

CD antigen modulator

Cytokine receptor antagonist

Energy metabolism modulator

ATP modulator

Superoxide dismutase modulator

Calcium Channel Blocker

Potassium Channel (KCN) Blocker

Type 1 Angiotensin II Receptor (AT1AR or AT1BR or Angiotensin II Type 1 Receptor or AGTR1) Antagonist

Kinase suppressor of Ras modulator

ENO1 Inhibitor

Mitosis inhibitor

Apoptosis modulator

Chemosensitizer

Purinoceptor antagonist

P2X purinoceptor modulator

Bacterial protein synthesis inhibitor

Aminoglycoside antibiotic

对表达受体酪氨酸蛋白激酶 ERBB 3 的细胞具有细胞毒性

Haven't applied yet（1）

已申请（23）

已过期

N/A（4）

1类（29）

2类（1）

3类

4类

5类

吸入性

瘤内（2）

静脉（12）

口服（9）

皮下（2）

外用

关节内

脑内（1）

冠状动脉内

皮内注射（1）

眼内

腹腔

鞘内

玻璃体内

鼻腔

眼科

注射用（1）

透皮

直肠

膀胱内

Global

US

EU(incl. Canada, Australia, New Zealand)

UK

JP

China, mainland

India

Israel

Korea

TaiWan

Others (e.g. ASEAN，Russia, South Africa, etc.)

License-out（74）

Co-R&D

Financing/M&A

CRO-Lab

CRO-Clinical

CMO/CDMO

CSO

MAH转移

医药/生物产业园

全球法规事务和档案支持

其他

Unknown

全球

美国

欧洲 (incl. Canada, Australia, New Zealand)

英国

日本

中国大陆

印度

以色列

韩国

台湾地区

其他 (如： 东盟，俄罗斯, 南非等)